Education & Human Development

Redox Biology & Cell Signaling Laboratory

  • Funding
    1. Sydney & JL Huffines Institute Amin Mohajeri (Student/post-doc), John M. Lawler (PI) 2020-2021. $1,500.
    2. NASA HRP Grant Augmentation Award Amin Mohajeri (student/post-doc), John M. Lawler (PI) 2020-2021. $30,000.
    3. Texas A&M University Office of the President T3 John M. Lawler (PI), Shaodong Guo (CoI, Thomas Kent (CoI) Triad (T3) grant “Novel Regulation in Assembly of the NADPH oxidase-2 (Nox2) Complex During Spaceflight in Skeletal Muscle: Short-circuiting Muscle Fiber Atrophy.” 2019-2020, $30,000.
    4. NASA (ROSBio 2018) (80NSSC19K0432) John Lawler (PI), Jim Fluckey (CoI) “Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Spaceflight.” 2019-2022, $750.000.
    5. NASA HERO (Human Exploration Research) 16-16Flag1_2-0043 (NNX80NSSC17K0118) JM Lawler (PI), JF Ford (CoI), N Turner (CoI). Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing. 2017-2020, $150,000.
    6. Sydney & JL Huffines Institute Seed Grant John M. Lawler (PI)  “Nox2 and Membrane Repair Protein Regulation in Unloading-induced Muscle Atrophy.” 2015-2016, $7500.
    7. National Space Biomedical Research Institute (NSBRI), NASA PF03504 NNH11ZTT002N First Award Program (Post-Doctoral Fellowship) John M. Lawler (PI), James Kuczmarski (Mentee),” Developing Novel, Targeted Countermeasures to Reduce Oxidative Stress and Skeletal Muscle Atrophy During Microgravity” 2014-2016. $102,000.
    8. NASA (Space Biology Program) NASA NNX13AE45G John Lawler (PI), Jim Fluckey (CoI) “Redox Regulation of nNOS Translocation and Muscle Atrophy During Mechanical Unloading” 2012-2018. $400,000.
    9. Sydney & JL Huffines Institute – Seed Grant John Lawler (PI) “Redox Regulation of nNOS During Disuse” 2011-2012, $7500.
    10. Office of the Vice President for Research (Texas A&M University) – Scholarly & Creative Products Program. John M. Lawler (PI), Guoyao Wu, CoI.  “Skeletal Muscle Atrophy During Mechanical Unloading as a Unique Muscular Dystrophy: Altering the Subsarcolemmal Environment.”  2011-2013, $18,000.
    11. Sydney & JL Huffines Institute Seed Grant John M. Lawler (PI) “Mechanical Unloading with Disuse Causes a Unique Muscular Dystrophy: Regulation of the Dystroglycan Complex and NF-kappaB Activation by Oxidative Stress” 2009-2010, $5500.
    12. NASA NSBRI (National Space Biomedical Research Institute). Nancy Turner (Co-PI) & Joanne Lupton (Co-PI), Jim Fluckey (CoI), John Lawler (Co-I), Steve Crouse (CoI), Sue Bloomfield (CoI), 6 other CoIs. “Ph.D. training program in critical areas of space life sciences.”  2006-2017, $1,200,000.
    13. American College of Sports Medicine Wook Song (Graduate Advisee) – 2002 NASA Space Physiology Research Grant.  “Oxidative Stress During Hindlimb Suspension.”  $2500.

 

  • Publication
  1. Hord, JM, MM Garcia, JM Kuczmarski, KR Farris, V. Guzzoni, Y Lee, MS Lawler, JM Lawler. Nox2 signaling and muscle fiber remodeling are attenuated by losartan administration during skeletal muscle unloading. Physiological Reports. 2021;9:e14606. PubMed Nox2 signaling and muscle fiber remodeling are attenuated by losartan administration during skeletal muscle unloading – PubMed (nih.gov)  | Google Scholar  Nox2 signaling and muscle fiber remodeling are attenuated… – Google Scholar
  2. Kuczmarski JM, JM Hord, Y Lee, V Guzzoni, D Rodriguez, MS Lawler, EE Garcia-Villatoro, D Holly, P Ryan, K Falcon, M Garcia, JD Fluckey, JM Lawler. EUK-134 modulates anabolic signaling in the rat soleus after 7 days of hindlimb unloading. Experimental Physiology. 103: 545-558, | PubMed | Google Scholar
  3. Lawler JM and JM Hord. “Redox Regulation of Protein Turnover During Unloading-induced Atrophy.” CrossTalk Debate 20: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis/proteolysis.  Invited Comment. Journal of Physiology, February 2015.  IF = 4.898 | PubMed | Google Scholar
  4. Lawler, J.M., M. Kunst, K. Joshi, J. Hord, Y. Lee, R. Botchlett, A. Ramirez, and D.A. Martinez. EUK-134 ameliorates nNOSμ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading. American Journal of Physiology.  306: R470–R482, 2014. [PMID: 24621789]  IF = 3.631 | PubMed | Google Scholar
  5. Lawler, J.M., H.B. Kwak, J.-H. Kim, Y. Lee, and J.M. Hord, and D.A. Martinez. Biphasic stress-response in the rat soleus during reloading following hindlimb unloading. Medicine and Science in Sports & Exercise. 44: 600-609, 2012.  [PMID: 21486793] (wrong PMID.  This PMID belongs to #69.) | PubMed | Google Scholar
  6. Lawler, J.M., W. Song, and H.B. Kwak. Differential regulation of heat shock proteins by hindlimb unloading and reloading in the rat soleus. Muscle & Nerve.  33: 200-207, 2006. [PMID: 16258950] | PubMed | Google Scholar
  7. Lawler, J.M., W. Song, and S.R. Demaree. Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle.  Free Radical Biology & Medicine. 35: 9-16, 2003. [PMID: 12826251] | PubMed | Google Scholar
  8. Lawler, J.M., C.C. Cline, J. O’Kroy, and J.R. Coast. Effects of inspired O2 and CO2 on ventilatory responses to LBNP-release and acute head-down tilt.  Aviation, Space, and            Environmental Medicine. 66: 751-756, 1995. [PMID: 7487808] | PubMed | Google Scholar
  9. Powers, S., J. Lawler, D. Thompson, and R. Beadle. Measurement of oxygen uptake in the non-steady state.  Aviation, Space, and Environmental Medicine.  58: 323-327, 1987. | PubMed | Google Scholar
  • Funding
    1. Department of Defense SBIR Program Jinseong Kim (PI), John M. Lawler (CoI) “Detection of Urinary Biomarkers for Assessment of Oxidative Status.” 2012-2013. $100,000.
    2. College of Education (Texas A&M University) – Instructional Enhancement Equipment Program (PI).  Integrated Forceplate and EMG System in Biomechanics”  2001, $13,773. 
    3. Office of the Vice President for Research and Associate Provost for Graduate Studies (Texas A&M University) – Minigrant John M. Lawler (P.I.).  “Will Exercise Training Improve Antioxidant Capacity in Skeletal Muscle of Pigs with Coronary Occlusion.”  2000-2001, $1,500.
    4. Center for Teaching Excellence (Texas A&M University) – Incentive Grant (P.I.). “Software and Hardware Development for Undergraduate Analysis of Movement Class (KINE 426).” 1992-1993, $1000.00.

 

  • Publication
  1. Lawler, JM, Guzzoni V, EE Garcia-Villatoro, JM Hord, JM Kuczmarski, JD Fluckey, S Talcott. Effect of combined fish oil plus curcumin on skeletal muscle morphology in the C57 mouse. Nutrition Research. 65:17-28, 2019. | PubMed | Google Scholar
  2. Hord, JM, Lawler JM. ROS and nNOS in the Regulation of Disuse-Induced Skeletal Muscle Atrophy. The Plasticity of Skeletal Muscle – From Molecular Mechanism to Clinical Applications. 2016. | PubMed | Google Scholar
  3. Lawler JM, D. Rodriguez, and JM Hord. Mitochondria in the Middle: Exercise Preconditioning Protection of Striated Muscle. Journal of Physiology.  594: 5161-5183, 2016.  IF = 4.898 | PubMed | Google Scholar
  4. Botchlett, R, JM Lawler, and G Wu. Arginine and citrulline in sports nutrition and health.  In Nutrition and Enhanced Sports Performance: Recommendations for Muscle Building.  Bagchi, S. Nair, and CK Sen (Eds)  pp 439-446, 2013. | PubMed | Google Scholar 
  5. Lawler, J.M., Z. Hu, J.S. Green, S.F. Crouse, P.W. Grandjean, and R.G. Bounds. Combination of estrogen replacement and exercise protects against HDL oxidation in post-menopausal women. International Journal of Sports Medicine.  23: 477-483, 2002. [PMID: 12402178] | PubMed | Google Scholar
  6. Lawler, J.M., W.S. Barnes, G. Wu, W. Song, and S.R. Demaree. Direct antioxidant properties of creatine.  Biochemical & Biophysical Research Communication.  290:47-52, 2002. | PubMed | Google Scholar
  7. Demaree, S.R., S.K. Powers, and J.M. Lawler. Fundamentals of exercise metabolism.  In: American College of Sports Medicine Resource Manual for Guidelines for Exercise Testing and Prescription.  4th Ed.  Williams & Wilkins: Baltimore MD, pp. 133-140  | PubMed | Google Scholar (similar Google Scholar link with #41).
  8. O’Kroy, J.A., J.M. Lawler, J. Stone, and T.G. Babb. Airflow limitation and regulation of end expiratory lung volume during exercise.  Respiration Physiology.  119: 57-68, 2000. | PubMed | Google Scholar
  9. Gonzalez, J., J.R. Coast, J.M. Lawler, and H.G. Welch. A chest wall restrictor to study effects on pulmonary function and exercise. 66: 188-194, 1999. [PMID: 10202329] | PubMed | Google Scholar
  10. Powers, S.K. and J.M. Lawler. Fundamentals of exercise metabolism.  In: American College of Sports Medicine Resource Manual for Guidelines for Exercise Testing and Prescription.  3rd Ed.  Williams & Wilkins: Baltimore MD, pp. 129-136, 1998. | PubMed | Google Scholar (similar Google Scholar link with # 49).
  11. Craig, B.N., J.J. Congleton, C.J. Kerk, J.M. Lawler, and K.P. McSweeney. Correlation of injury occurrence data with estimated maximal aerobic capacity and body composition in a high frequency manual handling tasks.  American Industrial Hygeine Association Journal.  59: 25-33, 1998. [PMID: 9438332] | PubMed | Google Scholar
  12. Mengelkoch, L., A.D. Martin, and J.M. Lawler. A review of the principles of pulse oximetry and accuracy of pulse oximeter estimates during exercise.  Physical Therapy.  74: 40-49, 1994. [PMID: 8265727] | PubMed | Google Scholar
  13. Lawler, J.M., S.K. Powers, J. Hammeren, and A.D. Martin. Oxygen cost of treadmill running in 24 month old Fischer-344 rats.  Medicine and Science in Sports and Exercise.  25: 1259-1264, 1993. [PMID: 8289613] | PubMed | Google Scholar
  14. Deason, J., S. Powers, J. Lawler, D. Ayers, and M.K. Stuart. Physiological correlates to 800 meter running performance.   Journal of Sports Medicine and Physical Fitness.  31: 499-504, 1991. [PMID: 1806725] | PubMed | Google Scholar
  15. Powers, S.K., S. Dodd, D. Criswell, J. Lawler, D. Martin, and S. Grinton. Evidence for an alveolar-arterial PO2 gradient threshold during incremental exercise. International Journal                  of Sports Medicine. 12: 313-318, 1991. [PMID: 1889942] | PubMed | Google Scholar
  16. Powers, S.K., S. Dodd, J. Lawler, and K. Wheeler. Effects of carbohydrate feedings                       during high intensity, short term exercise.  In: The Theory and Practice of Athletic Nutrition: Bridging           the Gap.  Wheeler (Ed).  Columbus, Ohio: Ross Laboratories.  pp. 1-10, 1989. | PubMed | Google Scholar
  17. Lawler, J., G. Landry, S. Powers, B. Baker, S. Dodd, R. Richard. Accuracy of the Ohmeda pulse oximeter in estimating heart rate during exercise.  Respiratory Care. 34: 724-727, 1989. | PubMed | Google Scholar
  18. Dodd, S., S. Powers., D. Thompson, G. Landry, and J. Lawler. Exercise performance following intense, short-term ventilatory work.  International Journal of Sports Medicine.  10: 48-52, 1989. [PMID: 2703284] | PubMed | Google Scholar
  19. Powers, S., S. Dodd, J. Lawler, G. Landry, M. Kirtley, T. McKnight, and S. Grinton. Incidence of exercise induced hypoxemia in elite endurance athletes at sea level. European Journal of Applied Physiology. 58: 298-302, 1988. [PMID: 3220070] | PubMed | Google Scholar
  • Funding
    1. College of Education & Human Development – Catapult Grant JM Lawler, C Wu, L Kuo, S Guo, J Fluckey. “Novel Approaches to Combatting Disuse Skeletal Muscle Atrophy: Breakthroughs in Mechano- and Nutrient-sensing.” 2018-2019, $30,000.
    2. Office of the Vice President for Research (Texas A&M University) – PESCA Program. John M. Lawler (PI), Joe Kornegay, CoI, JT Lightfoot (CoI), W Porter (CoI) “Nox2 Crosstalk and Regulation in Diaphragm Muscle with Dystrophin Deficiency.”  2015-2017, $25,000.
    3. NIH (NIAMS) (AR054084) John M. Lawler (PI).  “Regulation of Oxidative Stress in the mdx Diaphragm.” 2006-2011, $150,000.
    4. Muscular Dystrophy Association  John M. Lawler, (PI).  David S. Criswell; (CoI)  “Oxidative Stress and Inflammatory Cell Signaling in the Diaphragm and Limb Muscles of mdx Mice”  2003-2005, $75,000. 
    5. College of Education (Texas A&M University) – Seed Grant (P.I.). “Conjugated Linoleic Acid: Antidote for Oxidative Stress in the Heart” 2000, $ 2592.
    6. Office of University Research (Texas A&M University) – Minigrant.(P.I.). “Depression of diaphragm muscle oxygen consumption by peroxynitrite.” 1999, $1,494
    7. College of Education (Texas A&M University) – Seed Grant (P.I.). “Just say NO: Inhibition of antioxidant enzymes in diaphragm muscle by nitric oxide.” 1999, $4000. 
    8. Office of University Research (Texas A&M University) – Minigrant.(P.I.). “Influence of nitric oxide on calcium release and contractions in the diaphragm.” 1998, $1,440.
    9. American Lung Association – (P.I.). “Oxidative stress and diaphragm contractility.”  1996-1997,  $22,777 (Renewal).
    10. American Lung Association – (P.I.). “Oxidative stress and diaphragm contractility.”  1995-1996,  $20,919  (Score: 1st percentile).
    11. Office of University Research (Texas A&M University) – Program to Enhance Scholarly and Creative Activities (P.I.).  “Does the hydroxyl radical contribute to depression in contractility of the diaphragm induced by xanthine oxidase?” 1994, $7475.
    12. Office of University Research (Texas A&M University) – Minigrant. (P.I.). “Effect of desferrioxamine on XO-induced changes in diaphragmatic K+ contractures.”  1993-1994, $800. 
    13. Office of University Research (Texas A&M University) – Minigrant.(P.I.). “Effect of free radical stress on K+- induced contractures in the diaphragm.”  1992-1993, $800.00.  
    14. Office of University Research (Texas A&M University) – Minigrant.(P.I.). “Interaction of pH and free radical stress on fatigue in the diaphragm.”  1992, $500.00

 

  • Publication
  1. Kim, JH, LA Thompson, HB Kwak, JM Lawler. Contribution of oxidative stress to pathology in diaphragm and limb muscles with dystrophin deficiency.  Neuromuscular Disorders. 34: 1-13, 2013. [PMID: 23104273] | PubMed | Google Scholar
  2. Kim, J.-H. and J.M. Lawler. Amplification of pro-inflammatory phenotype, damage, and weakness by oxidative stress in the diaphragm muscle of mdx   Free Radical Biology & Medicine. 52: 1597-1606, 2012.   [PMID: 22330042] IF = 5.886 | PubMed | Google Scholar
  3. Lawler, J.M. Exacerbation of Pathology by Oxidative Stress in Respiratory and Locomotor Muscles with Duchenne Muscular Dystrophy. Journal of Physiology.  589: 2161-2170, 2011.  [PMID: 21486793]  | PubMed | Google Scholar
  4. Lawler, J.M., J.-H. Kim, H. B. Kwak, and W.S. Barnes. Redox Modulation of Diaphragm Contractility: Interaction Between DHPR and RyR Channels. Free Radical Biology & Medicine. 49: 1969-1977.   [PMID: 20920578] | PubMed | Google Scholar
  5. Hindle, A.G., Lawler, J.M., Campbell, K.L. and Horning, M. Muscle senescence in                 short-lived wild mammals, the soricine shrews Blarina brevicauda and Sorex         palustris. Exp. Zool. 311A, 358-367, 2009. [PMID: 19296507] | PubMed | Google Scholar
  6. Lawler, J.M. and W. Song. Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors.  Biochemical & Biophysical Research Communication.   294: 1093-1100, 2002.  [PMID: 12074589] | PubMed | Google Scholar
  7. Lawler, J.M., and Z. Hu. Interaction of nitric oxide and reactive oxygen species on contractility of the rat diaphragm.  Acta Physiologica Scandinavica. 169: 229-236, 2000. [PMID: 10886037] | PubMed | Google Scholar
  8. Powers, S.K., J.M. Lawler, and H.K. Vincent. The diaphragm and oxidative stress.  In:  Oxidative Stress in Skeletal Muscle.  Z. Reznick et al. (Eds).  Birkhauser Verlag: Basel, Switzerland, pp. 223-237, 1998. | PubMed | Google Scholar 
  9. Lawler, J.M., Z. Hu, and W.S. Barnes. Effect of reactive oxygen species on K+ contractures in the rat diaphragm.  Journal of Applied Physiology.  84: 948-953, 1998. [PMID: 9480956] | PubMed | Google Scholar
  10. Lawler, J.M. and S.K. Powers. Oxidative stress, antioxidant capacity, and the contracting diaphragm.  Canadian Journal of Applied Physiology.  23: 23-55, 1998. [PMID: 9494738] | PubMed | Google Scholar
  11. Lawler, J.M., C.C. Cline, Z. Hu, and J.R. Coast. Effect of oxidative stress and acidosis on diaphragm contractile function.  American Journal of Physiology. 273: R630-R636, 1997.    [PMID: 9277548] | PubMed | Google Scholar
  12. Powers, S.K., D. Criswell, J. Lawler, D. Martin, L.L. Ji, and G. Dudley. Regional training-induced increases in diaphragmatic oxidative and antioxidant enzymes. Respiration Physiology.  95: 227-237, 1994. [PMID 8191043] | PubMed | Google Scholar
  13. Lawler, J.M., S.K. Powers, and D. Criswell. Gender differences in diaphragmatic metabolic properties of the adult Sprague-Dawley rat. Respiration Physiology. 97: 263-273, 1994 [PMID 7973131] | PubMed | Google Scholar 
  14. Lawler, J.M., S.K. Powers, H. VanDijk, T. Visser, M. Kordus, and L.L. Ji. Metabolic and antioxidant enzyme activities in the diaphragm:  effects of acute exercise.  Respiration   96: 139-149, 1994. [PMID: 8059080] | PubMed | Google Scholar
  15. Powers, S.K., D. Criswell, J. Lawler, L.L. Ji, D. Martin, R. Herb, and G. Dudley. Influence of exercise and fiber type on antioxidant enzyme activity in rat skeletal muscle.      American Journal of Physiology.  266: R375-R380, 1994. [PMID: 8141392] | PubMed | Google Scholar
  16. Powers, S.K., D. Criswell, J. Lawler, D. Martin, F.K. Lieu, L.L. Ji, and R. Herb. Rigorous exercise training increases superoxide dismutase activity in the ventricular myocardium.  American Journal of Physiology.  265: H2094-H2098, 1993. [PMID: 8285249] | PubMed | Google Scholar
  17. Lawler, J.M., S.K. Powers, and D.S. Criswell. Inducibility of NADP-specific isocitrate dehydrogenase with endurance training in skeletal muscle.  Acta Physiologica Scandinavica.  149: 177-181, 1993. [PMID: 8266807] | PubMed | Google Scholar
  18. Criswell, D.S., S. Powers, S. Dodd, J. Lawler, W. Edwards, K. Renshler and S. Grinton. High intensity training-induced changes in skeletal muscle antioxidant enzyme activity. Medicine and Science in Sports and Exercise. 25: 1135-1140, 1993. | PubMed | Google Scholar
  19. Powers, S., J. Lawler, D. Criswell, H. Silverman, H.V. Forster, S. Grinton, and D. Harkins. Regional metabolic differences in the rat diaphragm. Journal of Applied Physiology. 69: 648-650, 1990. [PMID: 2228877] | PubMed | Google Scholar
  20. Lawler, J., S. Powers, and S. Dodd. A time-saving accelerated cycle ergometry protocol to determine peak VO2. British Journal of Sports Medicine.  21: 171-173, 1987. [PMID: 3435821] | PubMed | Google Scholar
  • Funding
    1. College of Education & Human Development – Transforming Lives Research Grant JM Lawler, J Kornegay “The Role of Nox2 and Loss of nNOS-mu in Aging Skeletal Muscle: Integrative and Translational Solutions.”  2015-2016, $30,000.
    2. American Heart Association – South Central Affiliate John M. Lawler (PI) “Regulation of MnSOD by Exercise Training Attenuates Remodeling and Apoptosis in the Aging Heart.”  2008-2011, $140,000.
    3. Sydney & JL Huffines Institute Seed Grant “Targeting Potential Upstream Mechanisms By Which Exercise Protects Against Age-induced Fibrosis and Matrix Metalloproteinase Dysregulation in the Heart” 2008-2009, $5000.
    4. American Heart Association – Texas Affiliate John M. Lawler (PI).  (AHA 0555064Y) “Exercise training protects against pro-apoptotic signaling in the aging heart.”  2005-2008, $124,000.
    5. National Science Foundation  Markus Horning (PI),  John M. Lawler  (Co-PI). (ANT 0649609)   “Aging in Weddell Seals:  Proximate Mechanisms of Age-Related Changes in Adaptations to Breath Hold Hunting in an Extreme Environment.”  2005-2010, $449,358. 
    6. Office of the Vice President for Research (Texas A&M University) – Proposal Planning Grant. John M. Lawler  (PI).  “Regular Exercise Protects Against Cell Loss and Apoptosis in the Aging Heart.”  2005-2006, $30,000. 
    7. American College of Sports Medicine Wook Song (Graduate Advisee) – 2002 ACSM Foundation Research Grant. “Exercise Training Reverses Age-induced iNOS Upregulation.”  $5000. 
    8. Office of the Vice President for Research and Associate Provost for Graduate Studies (Texas A&M University) – Program to Enhance Scholarly and Creative Activities (P.I.). “Oxidative Stress and Alterations in Cell Signaling Pathways in Aging Skeletal Muscle: Analysis Using “Gene Chip” Technology.”  2001-2002, $ 7,490. 
    9. Office of the Vice President for Research and Associate Provost for Graduate Studies (Texas A&M University) – Program to Enhance Scholarly and Creative Activities (P.I.). “Impact of Aging on Gene Expression of Neuronal Nitric Oxide Synthase in Rat Skeletal Muscle.”  2000-2001, $ 7,486.
    10. College of Education (Texas A&M University) – Seed Grant (P.I.). “Production of reactive oxygen species in the aging diaphragm.”  1998, $4000.
    11. College of Education (Texas A&M University) – Incentive grant (P.I.). “Is free radical-induced fatigue in the diaphragm enhanced with aging?”  1993, $1500.00. 
  • Publication
  1. Allen, KN, JP Vasquez-Medina, JM Lawler, JA Mellish, M Horning, and AG Hindle. Muscular apoptosis but not oxidative stress increases with old age in a long-lived diver, the Weddell seal. Journal of Experimental Biology. Jun 25;222(Pt 12). pii: jeb200246. doi: 10.1242/jeb.200246. | PubMed | Google Scholar
  2. Wu CS, Q. Wei, DM Kim, M Balderas, G Wu, J Lawler, S Safe, S Devaraj, Z Chen, and Y. Sun. Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice. Journal of Gerontology. 2018 Nov 8. doi: 10.1093/gerona/gly256 | PubMed | Google Scholar
  3. Guzzoni V, Marqueti RC, Durigan JL, Hernandes LR, Mekaro MS, Costa Santos TO, Mecawi AS, Hord JM, Lawler JM, Davel APC, Selistre-de-Araújo, HS. Reduced Collagen Accumulation and Augmented MMP-2 Activity in Left Ventricle of Old Rats Submitted to High-Intensity Resistance Training. Journal of Applied Physiology. 123: 655-663, | PubMed | Google Scholar
  4. Lee, Y., J. Hord, HB Kwak, JH Kim, and JM Lawler. Exercise Training Attenuates Age-Dependent Elevation of Angiotensin II Type 1 Receptor and Nox2 Signaling in the Rat Heart. Experimental Gerontology. 70: 163-73. 2015. [PMID: 26239262]  IF = 3.491 | PubMed | Google Scholar
  5. Hord, J.M., Y. Lee, R. Botchlett, J.H. Kim, JM Lawler. Lifelong exercise and mild caloric restriction against disruption of the dystrophin-glycoprotein complex (DGC) in skeletal muscle.  Experimental Gerontology. 83:148-57, 2016.  IF = 3.491 | PubMed | Google Scholar
  6. Kim, J.H., H.-B. Kwak, and J.M. Lawler. Lifelong wheel running and mild caloric restriction attenuate nuclear Endo-G in rat plantaris muscle.  Experimental Gerontology. 69: 122-128, 2015. [PMID: 26055450]  IF = 3.491 | PubMed | Google Scholar
  7. Kwak, H,-B., Y, Lee, and J.-H. Kim, H. Van Remmen, A.G. Richardson, and JM Lawler. MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. J Gerontology: Biological Sciences. 70: 533-44, 2015. [PMID: 25016531]  IF = 5.783 | PubMed | Google Scholar
  8. Lawler, J.M. and A. Hindle. Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia. Antioxidants & Redox Signaling.  May 4 EPub, 2011. [PMID: 21486793] | PubMed | Google Scholar
  9. Kwak, H.B., J.-H. Kim, K. Joshi, A. Yeh, D.A. Martinez, and J.M. Lawler. Exercise training reduces fibrosis and metalloproteinase dysregulation in the aging rat heart. FASEB Journal. 25: 1106-1117, 2011. [PMID: 21148111] | PubMed | Google Scholar
  10. Hindle, A.G., Lawler, J.M., Campbell, K.L., and M. Horning. Muscle aging and oxidative stress in wild-caught shrews. Comparative Biochemistry and Physiology, Part B, 155: 427-434, 2010. [PMID: 20109576] | PubMed | Google Scholar
  11. Lawler, J.M., H.-B. Kwak. Potential Exercise Mitigation and Regulation of Age-induced Apoptosis and Remodeling in the Heart. In “Modern Insights into Disease: Apoptosis.” December, 2009. | PubMed | Google Scholar
  12. Lawler, J.M., H.-B. Kwak, J.-H. Kim, and M-H Suk. Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats. American Journal of Physiology.  296: R1496-R1502, 2009. [PMID: 19297546] | PubMed | Google Scholar
  13. Song, W., H.-B. Kwak, and J.M. Lawler. Exercise training modulates the NOS profile in              skeletal muscle from old rats.  Journal of Gerontology Ser. A Biological Sciences and                      Medical Sciences.  64: 540-549, [PMID: 19304939] | PubMed | Google Scholar    
  14. Hindle, A.G., M. Horning, J.E. Melish, and J.M. Lawler. Diving into old age: muscular senescence in a large-bodied, long-lived mammal, the Weddell seal (Leptonychotes weddellii).  Journal of Experimental Biology.  212: 790-796, 2009. [PMID: 19251994] | PubMed | Google Scholar
  15. Lawler, J.M. Exercise protection against oxidative stress, apoptosis, and remodeling in  aging skeletal muscle.  Chapter In: Free Radicals in Biology and Medicine. C. Gutiérrez-Merino (Ed.), pp. 1-19, 2008. | PubMed | Google Scholar
  16. Kim, J.H., H.B. Kwak, C. Leeuwenburgh, and J.M. Lawler. Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress, and IGF-1 in the Fischer-344 rat.  Experimental Gerontology.  43: 317-329, 2008. [PMID: 18313875] | PubMed | Google Scholar
  17. Marzetti, M, J.M. Lawler, A. Hiona, T. Manini, A. Seo, and C. Leeuwenburgh. Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and caloric restriction in skeletal muscle.  Free Radical Biology & Medicine. 15: 160-168, 2007. [PMID: 18191752] | PubMed | Google Scholar
  18. Lawler, J.M., H.-B. Kwak, W. Song, and J. Parker. Exercise training reverses, downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion. American Journal of Physiology. 291: 1756-1763, 2006. [PMID: 16873555] | PubMed | Google Scholar
  19. Song, W. H.-B. Kwak, and J.M. Lawler. Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle.   Antioxidants & Redox Signaling.  8: 517-528, 2006. [PMID: 16677096] | PubMed | Google Scholar
  20. Kwak, H.-B., W. Song, and J.M. Lawler. Exercise-training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the aging rat heart.  The FASEB Journal.  20: 791-793, 2006. [PMID: 16459353] | PubMed | Google Scholar
  21. Lawler, J.M. and S.R. Demaree. Relationship between NADP-specific isocitrate dehydrogenase and glutathione peroxidase in aging rat skeletal muscle.  Mechanisms of Ageing and Development.  122: 291-304, 2001. [PMID: 11311317] | PubMed | Google Scholar
  22. Demaree, S.R., J.M. Lawler, J. Linehan, and M.D. Delp. Aging alters antioxidant enzyme activities in the aorta from Fischer-344 rats.  Acta Physiologica Scandinavica.  166: 203-208, 1999. [PMID: 10468656] | PubMed | Google Scholar
  23. Lawler, J.M., C.C. Cline, Z. Hu, and J.R. Coast. Effect of oxidant challenge on contractile function of the aging rat diaphragm.  American Journal of Physiology.  272: E201-E207, 1997. [PMID: 9124323] | PubMed | Google Scholar
  24. Lawler, J.M., S.K. Powers, T. Visser, H. VanDijk, M. Kordus, and L.L. Ji.  Acute exercise and skeletal muscle antioxidant and metabolic enzymes:  effects of fiber-type and age. American Journal of Physiology.  265: R1344-R1350, 1993. [PMID: 8285276] | PubMed | Google Scholar
  25. Tumer, N., C. Hale, J. Lawler, and R. Strong. Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by exercise: effects of age.  Brain Research, Molecular Brain Research.  14: 51-56, 1992. [PMID: 1353855] | PubMed | Google Scholar
  26. Hammeren, J., S. Powers, J. Lawler, D. Criswell, D. Martin, D. Lowenthal, and M. Pollock. Exercise training-induced alterations in skeletal muscle oxidative and antioxidant enzyme activity in senescent rats.  International Journal of Sports Medicine.  13: 412-416, 1992. [PMID: 1521960] | PubMed | Google Scholar
  27. Powers, S.K., J. Lawler, D. Criswell, F.-K. Lieu, and S. Dodd. Alterations in diaphragmatic oxidative and antioxidant enzymes in the senescent Fischer-344 rat.  Journal of Applied Physiology.  72: 2317-2321, 1992. [PMID: 1629087] | PubMed | Google Scholar
  28. Powers, S., J. Lawler, D. Criswell, F.-K. Lieu, and D. Martin. Aging and respiratory muscle plasticity:  effects of endurance training.  Journal of Applied Physiology.  72: 1068-1073, 1992. [PMID: 1568962] | PubMed | Google Scholar
  29. Criswell, D.S., S.K. Powers, J. Lawler, J. Tew, R. Tulley, Y. Iyriboz, and K. Wheeler. Influence of a carbohydrate-electrolyte beverage on performance and blood homeostasis during football.  Journal of Sports Nutrition.  1: 178-191, 1991. [PMID: 1844994] | PubMed | Google Scholar
  30. Powers, S., J. Lawler, D. Criswell, H.V. Forster, and H. Silverman. Age-related changes in enzyme activity in the rat diaphragm.  Respiration Physiology.  83: 1-10, 1991. [PMID: 2028101] | PubMed | Google Scholar
  31. Powers, S., J. Lawler, S. Dodd, R. Tulley, G. Landry and K. Wheeler. Fluid replacement drinks during heavy exercise:  effects on minimizing exercise-induced disturbances in homeostasis. European Journal of Applied Physiology. 60:  54-60, 1990. [PMID: 2311595] | PubMed | Google Scholar
  • Funding
    1. Mariana Janini Gomes – Visiting International Research Fellow, FAPESP Program, Botucatu School of Medicine, São Paulo State University, Botucatu, BRAZIL, 2017. $25,000
    2. Vinicius Guzzoni – Visiting International Research Scholar CAPES Program, UFSCAR, São Carlos, BRAZIL, 2014-2015, $25,000
    3. Office of the Vice-President for Research – Texas A&M University Travel Award – National Institutes of Health, 2004, $1300.
    4. Travel Award – College of Education (PI), 2001 $ 750
    5. University of Florida Grinter Research Fellowship, 1990 – 1991, $9,500  
    6. University of Florida Graduate Council Fellowship, 1989, $4,500
    7. Louisiana State University Lillian Oleson Scholarship, 1986 – 1988, $15,000

 

  • Publication
  1. Murray, I.V.J. and J.M. Lawler, F. Sohrabji, and J. F. Proza. Vascular and Metabolic Dysfunction in Alzheimer’s Disease: A Review. Experimental Biology & Medicine. 236: 772-782, 2011. [PMID: 21680755] | PubMed | Google Scholar
  2. Coast, J.R., R.A. Shanely, J.M. Lawler, and R.A. Herb. Lactic acidosis and diaphragmatic function in vitro. American Journal of Respiratory and Critical Care Medicine. 152: 1648-1652, [PMID: 7582309] | PubMed | Google Scholar
  3. Powers, S.K., S. Grinton, J. Lawler, D. Criswell, and S. Dodd. High intensity exercise training-induced metabolic alterations in respiratory muscles.  Respiration Physiology.  89: 169-177,1992. [PMID: 1439299] | PubMed | Google Scholar
  4. Grinton, S., S.K. Powers, J. Lawler, D. Criswell, S. Dodd, and W. Edwards. Endurance-training induced increases in expiratory muscle oxidative capacity.  Medicine and Science in Sports and Exercise.  24: 551-555, 1992. [PMID: 1533265] | PubMed | Google Scholar
  5. Powers, S., J. Lawler, D. Criswell, S. Grinton, and G. Bagby. Endurance training-induced cellular adaptation in respiratory muscles.  Journal of Applied Physiology.  68: 2114-2118, 1990. [PMID: 2361913] | PubMed | Google Scholar
  6. Powers, S., J. Lawler, J. Dempsey, S. Dodd, and G. Landry. Effects of incomplete gas exchange on VO2  Journal of Applied Physiology.  66: 2491-2495, 1989. [PMID: 2745310] | PubMed | Google Scholar
  7. Lawler, J., S. Powers, and D. Thompson. Linear relationship between VO2 max and VO2max decrement during exposure to acute hypoxia.  Journal of Applied Physiology.  64: 1486-1492, 1988. [PMID: 3378983] | PubMed | Google Scholar
  8. Powers, S., R. Beadle, D. Thompson, and J. Lawler. Ventilation and blood gas dynamics at the onset and offset of exercise in the pony.  Journal of Applied Physiology.  62: 141-148, 1987. [PMID: 3104284] | PubMed | Google Scholar
  9. Powers, S., R. Beadle, J. Lawler, and D. Thompson. Respiratory gas exchange kinetics in transition from rest or prior exercise in ponies.  Proceedings of the Second International     Conference on Equine Exercise Physiology.  2: 148-160, 1987. | PubMed | Google Scholar
  10. Powers, S., R. Beadle, J. Lawler, and D. Thompson. Oxygen deficit-debt relationships in the pony during treadmill exercise.  Respiration Physiology.  70: 251-263, 1987. [PMID: 3671903] | PubMed | Google Scholar